The Regional Service Centre in Entebbe (RSCE) was established in 2010  though General Assembly resolution 64/269 as part of the Global Field Support Strategy (GFSS). The overall objective of GFSS was to transform service delivery to field missions through a fundamental shift in the existing division of labor and a relocation of functions to improve responsiveness and address the needs of the field missions.  

The RSCE currently provides a full range of administrative, logistics and information and communications technology services to eighteen Client Missions in Africa, representing 75% of all United Nations peacekeeping and special political missions worldwide. The missions served include the United Nations Organization Stabilization Mission in the Democratic Republic of Congo (MONUSCO), the United Nations Mission in South Sudan (UNMISS), the United Nations Interim Security Force for Abyei (UNISFA), the African Union-United Nations Hybrid Operation in Darfur (UNAMID), the United Nations Multidimensional Integrated Stabilization Mission in the Central African Republic (MINUSCA), the United Nations Support Office in Somalia (UNSOS), the United Nations Assistance Mission in Somalia (UNSOM), the United Nations Multidimensional Integrated Stabilization Mission in Mali (MINUSMA), the Office of the Special Envoy of the Secretary-General to the Great Lakes Region (SESG-GL), the United Nations Regional Office for Central Africa (UNOCA), United Nations Mission for the Referendum in Western Sahara (MINURSO), the Office of the Special Envoy of the Secretary General in Burundi (OSESG-B), United Nations Office to the African Union (UNOAU), the Office of the Special Envoy of the Secretary-General for the Horn of Africa (SESG-HOA), United Nations Integrated Peacebuilding Office in Guinea-Bissau (UNIOGBIS), United Nations Support Mission in Libya (UNSMIL), United Nations Office for West Africa and the Sahel (UNOWAS), Cameroon-Nigeria Mixed Commission (CNMC) and UN Emergency Ebola Response Coordinator (EERC).

The General Assembly, though its resolution 69/307 decided to give the RSCE operational and managerial independence as of 1 July 2017. The Centre is now governed by a Steering Committee led by the Assistant Secretary-General for Field Support Operations and the Directors from the Department of Operational Support which is responsible for providing strategic guidance and oversight. In addition, the Directors and Chiefs of Mission Support of the RSCE’s Client Board provide expert advice to the Chief RSCE, including strengthening client management and engagement.